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[DOI] [PMC free article] [PubMed] [Google Scholar] Anton RF, Kranzler H, Breder C, et al

One study involving supplementation with CLA containing c9, t11, and t10, c12 isomers in a 50:50 ratio at a dose of 6.4 g/day in obese subjects for 12 weeks showed an increase in C-reactive protein (CRP) and interleukin-6 (IL-6) levels relative to both the placebo group and the lower dose CLA group (supplemented at a dose of 3.2 g/day) [23]