ghk-cu receptor downregulation evidence Glycyl‐l‐histidyl‐l‐lysine‐Cu2+ rescues cigarette smoking‐induced skeletal muscle dysfunction via a sirtuin 1‐dependent pathway - Deng - 2023 - Journal of Cachexia, Sarcopenia and Muscle Expression and Purification of Recombinant
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MMP modulation Simply building more collagen doesn't help if degradation continues unchecked

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10.1089/neu.2006.23.1828 J

At least, in cisplatin-resistant neuroblastoma cells, CuPDTC can induce cell death and cell cycle arrest by increasing TP53 protein expression, which usually leads to caspase-dependent apoptosis (Zhang et al., 2008)
