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P/LP, pathogenic or likely pathogenic

Patients with a personal or family history of medullary thyroid carcinoma represent another critical contraindication for tirzepatide-containing formulations

10.1016/j.psj.2021.101066 [DOI] [PMC free article] [PubMed] [Google Scholar] 218.Guo L, Lv J, Liu Y, Ma H, Chen B, Hao K, et al

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Importantly, impaired hepatic metabolic function can compromise carnitine biosynthetic capacity, potentially leading to relative deficiency that may contribute to hepatic lipid accumulation, inflammatory activation, oxidative stress, and insulin resistance