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10.1101/gad.299388.117 111 ZhaoX.SunW.RenY.LuZ

Amyloid-: an antioxidant that becomes a pro-oxidant and critically contributes to Alzheimers disease

Such marked locus heterogeneity underlying PD not only represents a major obstacle in identifying common disease mechanisms, but also restricts our options for appropriate therapeutic intervention

4.3 Controversies, open questions, and future directions Despite the promising role of VNS in modulating PD via the MGBA, several controversies and unresolved issues warrant attention