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Since 90% of the bodys serotonin originates in the gut, modulating enteric serotonin production could influence central serotonergic tone through vagal afferents that relay gut signals to brain serotonin-producing raphe nuclei
Biochem Soc Trans (2019) 47:4761

WangJWangTZhangYLiuJSongJHanYet al

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Improved glucose control: Targeting GLP-1 and GIP receptors, retatrutide demonstrates promising results in improving insulin sensitivity and glucose regulation

Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations