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36 However, when MRP2 function is impaired [e.g., in Dubin-Johnson syndrome], MRP3 levels increase to provide a compensatory pathway for hepatic efflux

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The formation of colonies was further impaired in ADH5 GCLM cells compared to ADH5 -single knockout counterparts, thus revealing an independent contribution of GSH biosynthesis and ADH5 to this phenotype (Fig

106 In line with these observations, both IDH1- and IDH2-mutant AML cells were found to be more sensitive to BCL-2 targeting than were the non IDH-mutant AML cells upon treatment with the small molecule inhibitor ABT-199

1 (download XLSX ATPase activity screening data with l-Cys and GSH used as putative substrates

Dizziness and lightheadedness: Opioid-mediated vasodilation and blood pressure reduction produce orthostatic hypotension and vestibular instability