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However, unlike in control cells, the activities of ACO2 and the Fe-S dependent respiratory supercomplexes were diminished to varying degrees following 20 h of cystine starvation in CHAC1-deficient cells (Supplementary Fig

The system that removes these toxic reactive oxygen species includes a host of enzymes including four enzymes Glutathione peroxidase (GPX)- GPX detoxifies peroxides with glutathione acting as an electron donor in the reduction reaction, producing glutathione disulfide as an end product

10.1111/j.1476-5381.2012.01858.x 92 O'BrienF

10.1371/journal.pone.0121610 4 AhmadS.AnsariJ

The CPZ-specific overlapping downregulated genes include key mediators of OL homeostasis and myelin integrity, such as MOG , MAG , OMG, PLLP , and GJB1

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling