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Lastly, the mechanisms of non-radical ROS have been leveraged therapeutically for treating infection (Fig

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Change in CYP2E1 and PDI protein levels It is known that CYP2E1 is an important hepatic drug-metabolizing enzyme that converts APAP to a hepatotoxic metabolite (NAPQI), and lack of CYP2E1 would make the mice insensitive to APAP-induced hepatotoxicity