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However, a relationship between CYP3A4 polymorphism and required dose adjustments has not been found [118,119,120,121]

Module conservation analysis The conservation of the association between the gene co-expression modules and PD was evaluated according to the enrichment of the modules in DEGs of PD patients and controls from five different sources 45,46,47,48,49,160

But this creates a cycle that is hard to break and easy to spiral into dependency