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The ORF encodes a single polyprotein that is co- and post-translationally processed by viral and host proteases into three structural proteins, capsid (C), precursor membrane (prM), and envelope (E), and the seven nonstructural proteins NS1, NS2A, NS2B, NS3, NS4A, NS4B, and NS5 [1]

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It is not uncommon for patients with extensive actinic damage to present with multiple lesions of AK, BD and sBCC, which can all appear clinically very similar