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Understanding these distinctions provides a more accurate framework for studying cartilage biology, connective tissue remodeling, extracellular matrix regulation, and musculoskeletal resilience.

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The click reaction was stopped and GSTP1 precipitated by the addition of a 10X volume of ice-cold acetone overnight at -20C

NCOA4-mediated ferritinophagy facilitates ferritin degradation in autolysosome, increases the cellular labile iron pool, triggers peroxidation of polyunsaturated fatty acid-containing phospholipids and activates ferroptosis induction (10,53,58)