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Local delivery of mRNA-encoding cytokines promotes antitumor immunity and tumor eradication across multiple preclinical tumor models

However, the exact mechanisms underlying these phenomena are not yet fully understood and clinical trials targeting NNMT have not been reported until now

doi:10.1016/S1474-4422(15)70016-5 Heo JM, Ordureau A, Paulo JA, Rinehart J, Harper JW (2015) The PINK1-PARKIN mitochondrial ubiquitylation pathway drives a program of OPTN/NDP52 recruitment and TBK1 activation to promote mitophagy

Specifically, it is suggested that neurotransmitters like dopamine and hormones such as testosterone are directly influenced by the parasite, which in turn affects healthoutcomes

Chatgilialoglu C, Ferreri C, Krokidis MG, Masi A, Terzidis MA