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Combined treatment of tesaglitazar with resveratrol decreased Ac-PGC1 levels that were elevated in tesaglitazar-fed mice (Figure 6E and Supplemental Figure 5A)

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Studies are also needed to determine which oxidative stress pathway (i.e., nitrosative, chlorinated or carbonyl stress) is quantitatively the most important in CKD patients

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By consistently lowering body weight, our patients frequently experience enhanced insulin sensitivity and better glycemic control