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Pharmacol Ther 2012

Clinical overview

Whitlock BK, Daniel JA, Wilborn RR, Maxwell HS, Steele BP, Sartin JL

Finally, we assessed possible DNA damage, including double-strand breaks, by measuring the -H2AX, a phosphorylated variant of histone H2A, as a marker

In addition, injection exposure caused (1) digestive-tract tumors in rats, gerbils, and hamsters, (2) tumors of the pancreas, small intestine, and abdominal cavity in guinea pigs, (3) leukemia or lymphoma in newborn and adult mice and lymphoma in adult rats, (4) blood-vessel tumors in guinea pigs, rabbits, and dogs, (5) mammary-gland tumors in rats, and (6) tumors of the heart (sarcoma) and at the injection site in hamsters
