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Sci Rep 8:7338
McKinley Shiflett, Mrs
30,31 Moreover, lipid metabolism in immune cells is closely linked to immune regulation in metabolic diseases, such as diabetes, obesity, and autoimmune diseases such as rheumatoid arthritis (RA)

Animal models confirm TMAOs pathogenic role: reducing plasma TMAO slows CKD progression (138), while TMAO accelerates diabetic nephropathy by activating NLRP3 inflammasome, promoting IL-1/IL-18 release, and worsening renal dysfunction/fibrosis (139)

All subjects completed two testing sessions, seven days apart, 90 minutes following oral ingestion of either 4.5 grams GPLC or 4.5 grams cellulose (PL), in randomized order
