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One emerging hypothesis is that thyroidectomy may offer therapeutic benefit in selected patients with Hashimotos thyroiditis who continue to experience significant symptoms despite achieving biochemical euthyroidism with LT4 therapy (51)

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5b) and further suggests an increased glycolytic activity of Gclc -deficient FoB, a dependence that is not observed in Gclc -deficient T cells 43

Aberrant activation of specific transcriptional programs has the capacity to greatly alter cellular state, driving oncogenesis and supporting cancer cell proliferation