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The occasional meat eater group exhibited a significantly greater reduction in TMAO levels after the fiber intervention compared to the regular meat-eating participants (mean difference [95% CI]: 1.96 [4.00, 0.083], p -value = 0.029)

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It has been observed that drugs that are substrates of CYP450 enzymes have a higher likelihood of causing DILI in a dose-independent manner, while drugs that are CYP450 inhibitors have a higher likelihood of generating DILI only when they are administered at high daily doses (Yu et al

Galvano et al., 2009[17]

While betaine and TMAO reductase are responsible for converting betaine and TMAO to TMA, respectively (Zuo et al., 2020)

Nervous System: Abnormal dreams, confusion, paresthesia, speech disorder, and thinking abnormalities