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Pharmacokinetically, canakinumab and rilonacept bear advantages over anakinra: 1) Their long half-life allows for less frequent applications (anakinra: daily, rilonacept: weekly, canakinumab: once every 8 weeks) and 2) due to their large molecular size elimination is mainly non-renal, which makes dosage adjustments in kidney disease as required with anakinra treatment unnecessary [91, 97, 98]

(2014) Melanocytes and melanin represent a first line of innate immunity against Candida albicans

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