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Acetyl-CoA produced from glucose is the most well-known substrate for the TCA cycle

Through the mechanisms involving vasodilation, antioxidant activity, anti-inflammatory effects, blood pressure regulation, protection against ischemia-reperfusion injury, and lipid metabolism modulation, melatonin contributes significantly to cardiovascular health

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In New Zealand, 2 mg modified-release melatonin tablets are approved but not funded for the short-term treatment of insomnia in adults aged 55 years or older