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Nu/MRI nude mice (males, 5 weeks of age, from Charles River) were used

2022;9:856216.doi:10.3389/fnut.2022.856216

EF: Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing original draft, Writing review & editing

A 3-year follow-up of 4,007 patients undergoing elective coronary angiography revealed a significant association between elevated plasma TMAO levels and increased risk of MACE (stroke, myocardial infarction (MI), or death) (Tang et al., 2013)

These fatty acids are a dense, crucial source of potential energy, but they cannot cross into the mitochondrial matrixthe innermost compartment where energy production occurswithout a specialized transport mechanism