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When iron overloads, hypoxia-inducing factor (HIF) is degraded and down-regulates iron-regulatory protein (IRP), which binds to iron-regulatory elements (IRE) linked to iron metabolism in brain tissue, inhibits the translation of TfR1 and DMT1 and promotes the translation of ferritin, FPN1, and APP (Rogers et al

Our in vitro studies have uncovered for the first time the ability of TNBS, a heterocyclic agent, to directly interact with the nucleophilic antioxidant, GSH, in a non-enzymatic fashion resulting in its almost instantaneous disappearance from the medium

In this chapter, lung cancer progression with various exposures, various kinds of lung cancer oxidants, and mutagenesis of oxidative stress in lung cancer, prevention, and therapeutic approaches are described

Polyphenols can exert antioxidant and immunomodulatory effects by targeting NF-B, thereby inhibiting tumor development (Guan et al., 2022)

Analysis of LRRK2, SNCA, Parkin, PINK1, and DJ-1 in Zambian patients with Parkinsons disease
