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In this paper, we summarize the prerequisites and defense systems for the occurrence of ferroptosis and the regulatory targets of drug-mediated ferroptosis action in HCC, the differences and connections between ferroptosis and other programmed cell deaths

It functions as a coenzyme, mediating various reactions in energy production, and regulating processes like DNA repair, gene expression, and cellular responses to stress

The adjustments are as follows: (1) For simplicity, we treat cytosolic serine and glycine as constant

Oxidative stress occurs when oxidants (reactive oxygen species) outweigh available antioxidants

and stilbenes (resveratrol), which influences stress signaling pathways and promotes the activation of AMPK, impacting mitochondrial metabolism in addition to the activity of FOXO and sirtuin
