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In this study, fibrosis and mononuclear cell infiltration were observed in the left ventricle of the heart upon histological evaluation of the myocardium of ISO-administered rats

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Previous studies have demonstrated that fluoromethylcholine (FMC), a non-lethal, microbe-friendly inhibitor of CutC lyase, significantly reduces plasma TMAO levels by irreversibly modifying the enzymatic pair CutC/D within gut microbiota harboring the corresponding gene cluster (Gupta et al., 2020)

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It is noteworthy that the administration of LCAR was able to suppress the expression of P62, while the expression of LC3 remained higher than that of the control group in the current study
