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Glucagon actually increases blood sugar, but when you combine it with a GLP-1, it can actually increase energy use and fat burning

Cortez-Pinto H, Chatham J, Chacko VP, Arnold C, Rashid A, Diehl AM

This attenuation is explained in part by shifting complier composition: As GLP-1 diffusion expands, the marginal patients induced into treatment become progressively healthier

All the data are presented as the mean standard error of the mean (S.E.M.)

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These peptides regulate energy homeostasis by acting directly on target tissues as hormones or by activating intrinsic and extrinsic neurons in a paracrine manner 9,10