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investigated the effects of an oral B vitamin regimen inclusive of B12 in prevention of the development of CIPN in a population of patients with neoplastic disease commencing chemotherapy

The associated S plot (Fig 2A) indicated the NMR chemical shifts, then assigned to metabolites, that discriminated between the two classes (Figs 2C and S3)

She had a smooth, red tongue without lingual papillae, suggestive of glossitis (Figure 1A)