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Vitamin B12 has an excellent safety profile, with the NHS stating that up to 2,000 micrograms daily is unlikely to cause harm

If you know your levels are low, B12 supplements are a great start, but you're going to be playing catch-up, so dont expect things to be back to normal immediately

Int J Pharm 1999

Leptin responsiveness restored by amylin agonism in diet-induced obesity evidence from nonclinical and clinical studies

Another element that plays a role in myelopathies caused by B12 deficiency is the disturbance of neuronal lipid and protein synthesis, which includes fundamental elements such as myelin proteins that create myelin sheaths in the spinal cord and peripheral nervous system (PNS) [83]