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Since KEAP1 negatively keeps the basal protein levels of NRF2 through the KEAP1-Cul3-RBX1 E3-ubiquitin ligase complex (see chapter 3.2), somatic mutations of KEAP1 abolish this protein-protein interaction with NRF2 and lead to NRF2 activation, which is targetable in lung cancer therapy

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A novel folic acid receptor-targeted drug delivery system based on curcumin-loaded -cyclodextrin nanoparticles for cancer treatment

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