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These radicals are highly reactive and can initiate lipid peroxidation and cause DNA damage

Nonetheless, whether the specific mechanism of this is related to the transdifferentiation of VSMCs to a bone-like phenotype, loss in SMC lineage markers, enhanced pro-calcific microRNAs, increased intracellular calcium level, apoptosis, or aberrant DNA damage response (DDR) requires further investigation

Wang Y, Gao W, Shi X, et al

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Neurochem Res 29(3):601608 Borowicz-Reutt KK, Czuczwar SJ (2020) Role of oxidative stress in epileptogenesis and potential implications for therapy

The impact of probiotics, prebiotics, and synbiotics on the biochemical, clinical, and immunological markers, as well as on the gut microbiota of obese hosts