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found that Dex (50 gkg 1 ) mitigated doxorubicin-induced cardiotoxicity in mice through the same pathway [40]

doi: 10.1111/aogs.13523 40

Briefly, sgRNA complexes were synthesized by mixing equal volumes of crRNA (2 l, 160 M in nuclease-free water, ggcgccagccatggacaatc) and tracrRNA (2 l, 160 M) and incubated at 37 C for 30 min before Cas9 (2.7 l, 10 g l 1 , Alt-R SpCas9 nuclease V3, 1081058) and duplex buffer (1.3 l

System Xc pathway The glutamate-cysteine anti-transport system (System Xc ) consists of 12 transmembrane transporters (Solute Carrier family 7 member 11, SLC7A11) and single-channel transmembrane regulatory proteins (Solute Carrier family 3 member 2, SLC3A2) (35), which can be transferred at a ratio of 1:1 out of glutamic acid and into cystine in an ATP-dependent manner (3)

Take 1 capsule daily with a glass of water