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Impairment of autophagic degradation and mitochondrial dysfunction are also significant factors, as evidenced by accumulation of autophagosomes and suppression of mitochondrial oxygen consumption rates in DOX-treated hearts [14]

[DOI] [PubMed] [Google Scholar] Traidl-Hoffmann C

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Xu J, Gao H, Zhang L, Rong S, Yang W, Ma C, et al

Intriguingly, when older mice were given MOTS-c injections to restore their MOTS-c to more youthful levels, it reversed certain aging effects specifically, it restored insulin sensitivity in aged muscles and improved the animals exercise capacity to levels comparable with younger mice