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These diphosphate synthases catalyze the formation of polyprenyl diphosphates with various chain lengths, making them the key enzymes in the biosynthesis of many isoprenoid compounds, such as PQ and UQ, vitamin E, carotenoids, and others [40]

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*Correspondence: Lanhuan Meng, [email protected] This article was submitted to Nutrition and Food Science Technology, a section of the journal Frontiers in Nutrition Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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In the cytosol and nucleus, several enzymes create localized ROS microdomains: xanthine oxidoreductase (interconverting XDH and XO) at cytosolic and endothelial surfaces, monoamine oxidases on the outer mitochondrial membrane facing the cytosol, dihydrolipoamide dehydrogenase within the PDH/OGDH complexes and NOX isoforms positioned at the nuclear envelope (Moloney et al

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357, e2300569

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Theodossiou et al ., 2019

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