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A direct link between enhanced ROS and decreased sGC expression was established by Gerassimou and colleagues (86), showing that exposure of smooth muscle cells to exogenously applied ROS-generating agents caused a decrease in 1 and 1 sGC subunit levels, thus attenuating cGMP formation

The olfactory region comprises just 35% of the total nasal cavity surface area yet is the most critical anatomical region regarding IN drug administration [17]

126 Intrinsic hepatotoxic reactions are dose-related and occur shortly after a consistent threshold of toxicity is reached

It can also be targeted in IBD treatment through the use of antioxidants, including vitamin C, vitamin E, glutathione, and N-acetylcysteine

CCM identifies nerve damage before symptoms or electrophysiological abnormalities appear [45, 46]

Bauman JE, Hsu CH, Centuori S, et al