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Dysfunctional ETC, in turn, further enhances ROS production and increases the disruption of the mitochondrial respiratory function and mitochondrial integrity [129]

Out of the top 20 gene sets enriched in each condition, 9 gene sets, including Heme metabolism and ROS pathway, were common to all 4 conditions and an additional 3 gene sets, including Cholesterol synthesis were enriched in 3 out of 4 conditions (Figure 3B, S3AB)

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Individuals with repeated injuries show increased risk for greater cognitive impairment and persistence of symptoms