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In extremely rare cases, a patient may develop a severe allergic (anaphylactic) reaction to gadolinium contrast medium

The absence of established treatment protocols makes it difficult to determine optimal dosing regimens, treatment duration, and comprehensive monitoring requirements

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Furthermore, citrate is an intermediate for sterol and fatty acid biosynthesis 614,615 and is used in astrocytes for the production of cholesterol, supporting synaptogenesis 616 , lipogenesis and lipid droplet formation in astrocytes 614,615