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This is the standard injection schedule

Blood samples collection procedure For the PK study, heparinised blood samples were collected at time 0 (baseline), 9.5 min (end of pemetrexed infusion), 15, 30, 50 min (end of vinorelbine infusion), 1 h, 1 h 20 min, 2, 4, 8, 24, 48 and 72 h, for measurement of plasma pemetrexed and vinorelbine concentrations over a 72-h period following the start of pemetrexed administration in first cycle

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The broader context of peptide legality and regulatory status is important for researchers to understand

The type of treatment depends on the severity of deficiency and whether absorption is an issue