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That there exist interspecies differences in biosynthetic pathways mediated by gut microbiota metabolism between mice and humans is consistent with numerous other examples of how gut microbiomes of mammalian species can differ (44)

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As a result, an increase in skeletal muscle total carnitine content may provide more effective buffering of acetyl-CoA production during high-intensity exercise, counteracting the increase in the acetyl-CoA/CoASH ratio and enhancing PDC flow and mitochondrial ATP production [23]