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is crucial in COPD pathogenesis

The multifunctional enzyme encoded by the MTHFD1 gene converts 5,10-methylene-THF to 10-formyl-THF which is required for the synthesis of the purine nucleotides

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These substances help prevent or slow the progression of neurodegenerative diseases, such as Alzheimers and Parkinsons disease

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However, results from meta-analyses of IPD are likely subject to retrieval bias and awareness of these limitations and their potential impact on findings is required (table 1)