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Under oxidative stress and induced by excessive ROS generation, Nrf2 is released from its inhibitor Keap1, allowing its translocation into the nucleus (Kasprzak et al., 2020), where it binds to the antioxidant response element (ARE) present in the DNA sequence of numerous antioxidant enzymes like glutathione-S-transferase, -glutamyl cysteine synthetase (glutamate cysteine ligase), heme oxygenase 1, and paraoxonase-1 inducing their transcription, managing the phase II response to oxidative stress (Kasprzak et al., 2020)

Salmanca is rich in bioactive compounds, such as phenolic acids and flavonoids

Arch Pediatr Adolesc Med 2007

Chronic HCV infection has been associated with higher expression of 8-OHdG, an indicator of oxidative DNA damage, which may lead to carcinogenesis 83,109

Recent studies have indicated that liposomes, polymer nanoparticles, and solid lipid nanoparticles could cross the BBB via passive transport [75, 77, 78]