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Possible physical explanations for Mpembas effect include the theory that during freezing, a patch of ice begins to form on the surface of the cold water, which acts as insulation and temporarily slows the freezing, whereas in hot water, conductive currents are created that mix the contents of the container and keep it from freezing from the top

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The latter result likely reflects a hydrophobic contribution to binding involving the aromatic tyrosine side chain

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Think of it as a more targeted, focused intervention compared to Retatrutides multi-system assault