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This maintains timing optimization while preserving tissue health and absorption consistency

Signal Transduct Target Ther

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10.1111/and.12196 65 SaleemA.SaleemM.AkhtarM

CaMKII Activation is Required for AMPH-induced Catecholamine Transporter Internalization, but not for EAAT3 Internalization or RhoA Activation Earlier studies have found that phosphorylation activities of the Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) is a critical component of DAT [10, 11] and NET [6, 12] trafficking in response to AMPH in various cell models, but we wanted to address if this was true in our cultured neurons