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Using a two-color system, they demonstrated that 32% of cases contained a significant number of smooth muscle actin-positive cells, interpreted by them as representing myofibroblasts, admixed with the neoplastic spindled melanocytes and representing the putative source of the desmoplasia in these neoplasms

As a result, some individuals may notice that existing freckles or moles become darker or more noticeable, particularly when combined with UV exposure

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[DOI] [PubMed] [Google Scholar] 39.Buchner A, Merrell PW, Carpenter WM

Solid tumors after hematopoietic stem cell transplantation in Japan: incidence, risk factors and prognosis

This process is called melanogenesis, where melanocytes make more melanin