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This experiment of nature emphasizes the importance of androgens, which act as inducers and activators in evolution of male gender identity in man (5, 6, 13, 1820)

These pathways are activated in response to OS, leading to apoptosis and inflammation, further contributing to neurodegeneration

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Alterations in GH/IGF-1 can impact the hypothalamic-pituitary-gonadal axis, which may modulate LH and FSH