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On a broken surgery door window

Kivimki M, Hamer M, Batty GD, Geddes JR, Tabak AG, Pentti J, et al

Certain synthetic nootropics may be restricted or fall into legal gray areas

Cyanocobalamin (vitamin B12) as a metabolite, activates the metabolism of carbohydrates, proteins and lipids, promotes the synthesis of labile groups in the formation of choline, methionine, nucleic acids, creatine, the accumulation in erythrocytes of compounds with sulfhydryl groups

That structural feature is significant: proline residues resist proteolytic cleavage, making the peptide unusually stable in gastric conditions relative to most short peptides [1]

Or, and this is a bigger question, might carnivores already sidestep many of the underlying metabolic issues that make higher-dose supplementation so impactful in the first place