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for instance, iron accumulation in microglia and astrocytes promotes the release of proinflammatory cytokines, exacerbating neuroinflammation and neuronal damage (Ryan et al., 2023

doi: 10.5187/jast.2023.e29 22 Payan-CarreiraR

Determination of the k microscopic redox equilibrium constants from the K C conditional equilibrium constants and related parameters is demonstrated below with the example of the k B redox microconstant

Perspective We will discuss how the current splitting paradigm can be integrated with a lumping perspective, which converges upon impaired mitochondrial biology as the etiology and core disease in the most common neurodegenerative disorders

intriguingly, once cleaved from a phospholipid, the oxidized PUFA tail no longer drives cell death (Figure 2)

Cold atmospheric plasma as a emerging hybrid redox modulation tool Cold atmospheric plasma (CAP), a fourth state of matter, represents a uniquely versatile therapeutic platform that directly addresses the fundamental dichotomy in redox biology by inherently coupling the generation of short-lived, highly reactive radical species (e.g., OH, O, NO) with longer-lived, diffusible non-radical oxidants (e.g., H 2 O 2 , nitrite/nitrate, and ONOO -derived species) in a single, tunable delivery system [5, 195, 196, 259, 262265]