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Start conservatively

But it was not enough for the very occasional patient

The recent discovery of pharmacological ABHD5 ligands that disrupt the interaction between ABHD5 and PLIN1 (48) demonstrate that the dissociation of ABHD5 is sufficient to stimulate adipocyte lipolysis and that these protein interactions can be targeted pharmacologically (34, 48, 49)

Data availability Raw DDA and PRM data from synthetic phosphopeptide analysis, DeepPhospho generated spectral libraries, and DIA search results have been deposited to the ProteomeXchange Consortium 43 via the iProX 44 partner repository with the dataset identifier IPX0003513000, which is equivalent to PXD028601

doi:10.2174/1874609810801030263 9

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