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doi: 10.1038/s41392-022-01078-9 272 Parker-AthillE

Notably, siNCOA4 induced a non-significant trend toward increased ASCL4, XCT, and decreased GPX4, whereas Ag intervention significantly amplified these responses to statistical significance, indicative of Ag-driven lipid peroxidation potentiation (Fig

4J), suggesting that PGC1 is one of the TFE3 targets regulating the phenotypes of Lyso-high GBM cells

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Research protocols should account for receptor sensitivity, IGF-1R expression levels in the model system, exposure duration, signaling saturation thresholds, dose-response behavior, and peptide stability under laboratory conditions