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Description Description Cyanocobalamin or Vitamin B12 prevents and treats deficient levels of Vitamin B12

Some factors, such as individual features or unknown molecules, may lead to antibody production against cobalamin, during the vitamin B12 replacement treatment

Current evidence suggests that high-dose B12 supplementation can trigger acne in susceptible people by altering skin bacteria behaviour, though this does not affect everyone

After absorption, B12 is bound to transport proteins, 7580% to haptocorrin, which transports B12 in the blood, and 2025% to transcobalamin, which delivers B12 to the tissues, also referred to as active B12 or holo-transcobalamin

For individuals experiencing chronic fatigue or low energy, evaluating B12 deficiency can be a crucial step

However, in guidelines published in 2012, the British Columbia Medical Association (Canadian Ministry of Health) recommended a dose of 1000 g/day for pernicious anemia or food-bound cobalamin malabsorption [34]