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The orobuccal and sublingual routes have been explored to overcome oral glutathiones absorption and bioavailability challenges: Orobuccal formulations: Glutathione is absorbed directly in the oral cavity, which generates much quicker absorption and considerably higher bioavailability

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Other molecules secreted by the cerebral endothelial cells include a variety of vasoactive factors such as the vasodilator, NO, and vasoconstrictor such as endothelin-1 (Durieu-Trautmann et al, 1993)

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