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Furthermore, the more recent observational data suggesting that the combination of high folate and low vitamin B-12 is associated with the worsening of both clinical outcomes and elevations in functional biomarkers of vitamin B-12 (23, 40, 41) imply that depletion of holoTC is attained even without stimulating hematopoiesis

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Though human data remains sparse

Efficacy is

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In the study of the elderly participants of NHANES 19992002, the combination of high circulating UMFA and vitamin B-12 deficiency was related to lower cognitive test scores (90)