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In human populations, selenium deficiency, due to lack of selenium in the soil, has been found to cause Keshan disease (6, 138, 216, 305), a cardiomyopathy, and Kashin-Beck disease (287, 393), an osteoarthropathy, in part, due to reductions in GPx-1 expression

Luteolin potentiated insulin signaling mainly via the pAkt/pGSK/pTau pathway, whereas l-theanine primarily reduced TNF- [98]

In the case of the severe disease group, androstenols were significantly decreased (considering 3 metabolites)

A 2025 systematic review confirmed that probiotic supplementation in T2DM patients leads to a significant elevation in total antioxidant capacity (TAC) and a reduction in malondialdehyde (MDA), a marker of lipid peroxidation (442, 443)

Methods : Therapeutic exercise was applied as an interventional method which can be used to improve the clinical picture of the patients

Challenges in Se-Based Thyroid Therapies Narrow Therapeutic Window and Risk of Selenosis Although it is beneficial in insignificant amounts, it has a narrow therapeutic window